The principal cytochrome P450 isoenzyme associated appears being CYP2E1, with CYP1A2 and CYP3A4 as supplemental pathways. Close to 85% of the oral dose seems during the urine within 24 hours of administration, most as being the glucuronide conjugate, with small amounts of other conjugates and unchanged drug.acute or intense bronchial asthma in an u